An Unbiased View of pkrrating
The interfacial residues are hugely conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements exhibit the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assist a model where by activating RNA serves to be a scaffold to bind numerous PKR monomers, escalating the co